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. Author manuscript; available in PMC: 2014 Feb 22.
Published in final edited form as: Oncogene. 2012 Sep 10;32(34):4017–4027. doi: 10.1038/onc.2012.408

Figure 5. AKT inhibition induces cell death and GAPDH nuclear accumulation.

Figure 5

Untransduced SK-N-SH cells were treated in the absence and presence of either 10 or 25 μM AKT inhibitor VIII (AKTi-VIII) for 48 h. (a) Analysis of cytoplasmic and nuclear fractions was performed as in Figure 3a, n=4. (b) AKT inhibition induces SK-N-SH cell death. Cell death was determined as in Figure 1b. Data represent means ± SEM, n=4. Immunoblot analysis of whole cell lysates, n=3. (c) SK-N-SH cells were treated as in (a) and GAPDH cellular localization was visualized as in Figure 3c.