TABLE 3.
Relative bioavailability estimates and 90% CI of posaconazole administered under nonfasting conditions relative to posaconazole administered under fasting conditions
| Parameter (unit) | With antacid
|
Without antacid
|
||||
|---|---|---|---|---|---|---|
| Bioavailability estimatea | 90% CI | P | Bioavailability estimatea | 90% CI | P | |
| Cmax (ng/ml) | 330 | 256-426 | 0.001 | 422 | 327-544 | 0.001 |
| AUCtf (ng · h/ml) | 308 | 247-384 | 0.001 | 400 | 321-498 | 0.001 |
a
Expressed as a ratio of posaconazole under nonfasting conditions to that under fasting conditions.