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. 2013 Jan;23(1):12–22. doi: 10.1101/gr.139469.112

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© 2013, Published by Cold Spring Harbor Laboratory Press

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Figure 2. — GATA3-dependent ESR1-binding events show distinct transcription factor co-occupancy and histone modifications. (A) A binary co-occupancy analysis showing the percentage of the ESR1 categories affected by depletion of GATA3 normally co-occupied by GATA3 and/or FOXA1. GATA3 and FOXA1 binding is from wild-type MCF7 cells. (Data from Hurtado et al. 2011.) (B) Averaged signal intensity of H3K4me1 and H3K27Ac active histone marks in unstimulated (Veh) and estrogen (E2)-treated cells centered on the different categories of ESR1 binding influenced by silencing of GATA3. (C) De novo motif analysis (Weeder).