Figure 2.

(A) Chromosomal organization of the LRRC37 family among primates. FISH results on primate metaphase chromosomes are shown for Lemur catta (LCA), Callithrix jacchus (CJA), Macaca mulatta (MMU), and Pongo pygmaeus (PPY). The following BACs were used as probes in each species: LCA chr17 (LB2-169E11 in red), CJA chr5 (CH259-152N22 in red and CH259-145C2 in green), MMU chr16 (CH250-219M3, CH250-221J22, and CH250-197J22 in red, green, and blue, respectively), and PPY chr17 (CH253-10O4, CH253-149E2, and CH253-167E20 in red, green, and blue, respectively). The corresponding LRRC37 family members are shown next to each chromosome. (B) Model of the LRRC37 family evolution. Different LRRC37 types are colored according to the human schematic. For other species, genes corresponding to syntenic locations or derived from lineage-specific duplications are colored corresponding to their human paralog. Since lemur copies are highly homogenized, we could not determine whether the ancestor of the human F copy emerged in the primate or the Haplorhini ancestor (dashed lines). Orthology relationships between human A type (A4 and A5) and marmoset 1–6 copies could not be determined (red-orange lines).