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. 2013 Jan;23(1):46–59. doi: 10.1101/gr.138842.112

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© 2013, Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported License), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 5. — Selection of the LRRC37 ancestral locus during mammalian evolution. (Middle) The exon-intron gene structures of cow LRRC37A, dog LRRC37A, rat Lrrc37a1, mouse Lrrc37a1, rat Lrrc37a2, mouse Lrrc37a2, macaque MMU1, human LRRC37A4, and human LRRC37A are shown, with start and stop codons indicated by a green and red sign, respectively. The additional block in human LRRC37A4 exon 9 is shown in gray. (Right) Motifs identified in the translated proteins are shown: SP (signal peptide), RPT (repetitive segments), LRR (leucine-rich repeat motifs), and TM (transmembrane helix). Rat coding sequence is incomplete at 5′ and lacks the start codon. The premature stop codon in human LRRC37A4 coding sequence removes the portion encoding the transmembrane domain. (Left) Branch estimates for ω = d_N/d_S for exons 2–8 are shown using the free branch model in PAML. Significant branches compared to a neutral model are indicated with an asterisk.