Table 4.
Specific Adverse Events Leading to Termination of Protocol Therapy
| Cycle | Patient | Adverse Event | Grade | Relationship to Study Drugs |
|---|---|---|---|---|
| 1 | 15 | MAI infection | 2 | Unlikely |
| Dyspnea | 4 | Possible | ||
| 3 | 26 | Confusion | 4 | Unrelated |
| 9 | Pneumonitis | 3 | Unlikely | |
| 5 | 16 | Anemia | 2 | Probable |
| Neutropenia | 3 | Probable | ||
| Thrombocytopenia | 3 | Probable | ||
| 20 | Catheter-related infection | 4 | Possible | |
| 10 | Palmar-plantar erythrodysesthesia syndrome | 3 | Definite | |
| 18 | Neutropenia | 3 | Probable | |
| 6 | 12 | Fatigue | 3 | Probable |
| 24 | Anorexia | 3 | Probable | |
| Optic Nerve Disorder | 4 | Unrelated | ||
| Gait disturbance | 2 | Unlikely | ||
| Cognitive disturbance | 2 | Unrelated | ||
| Dizziness | 2 | Unrelated | ||
| Leukoencephalopathy | 1 | Possible | ||
| Peripheral motor neuropathy | 3 | Unlikely | ||
| Palmar-plantar erythrodysesthesia syndrome | 3 | Probable |
Abbreviation: MAI, Mycobacterium avium intracellulare.