Figure 1.

Analysis method in order to find DMRs associated with BERs. ROMA genome-wide copy number profiles from breast tumors were combined to partition the genome into variable intervals of stable copy number state in which we estimate DNA methylation levels using MOMA measurements from tumor and Normal samples. A Hotelling’s T²-test is performed to identify significant DMRs. On the other track, the locations of BERs are obtained from the ROMA profiles and the list of both significant DMRs and BERs are further evaluated for statistical association (Figure 3).