Figure 7.

Response learning and free choice relearning in HPC-lesioned animals. Veh and IA animals underwent response learning in the 1st week and free choice learning in the 2nd week (R-F_r). (A1–A4) Mice from both treatment groups performed equally well upon response training. However both groups failed to reach the accuracy criterion because 4/13 Veh and 5/13 IA animals had adopted a “wrong” response indicated by accuracy levels below 17%. Therefore, we additionally cleared the data from these animals and re-examined training performance for both weeks. (B1–B3) IA mice had no impairments in response learning in the 1st week but showed a reduced accuracy and a higher latency as well as more wrong platform visits in the 2nd week [Treatment: F_{(1, 15)} ≥ 5.25, p ≤ 0.036]. However animals of both groups reduced the latency and the wrong platform visits over time in the 2nd week [Day: F_{(4, 60)} ≥ 47.65, p < 0.001]. (B4) Until d5_r, 5/9 IA mice still reached the accurate learner criterion in the 2nd week as opposed to 9/9 Veh controls (cf. Figure 8D).