Table 1.
Consequences of HPC lesions on basic exploration and anxiety-related behavior.
| Test | Parameter | Sham | HPC lesion | Statistics |
|---|---|---|---|---|
| Open field | Immobility time | 383 ± 10 s | 287 ± 11 s | t(69) = 6.333, p < 0.001 |
| Distance | 3463 ± 133 cm | 5887 ± 430 cm | t(69) =5.068, p < 0.001 | |
| Rearing (number) | 252 ± 9 | 258 ± 10 | t(69) = 0.488, p = 0.627 | |
| Rearing (duration) | 327 ± 13 s | 250 ± 12 s | t(69) = 4.306, p < 0.001 | |
| Center time | 36 ± 2% | 27 ± 2% | t(69) = 3.180, p = 0.002 | |
| Center distance | 36 ± 2% | 25 ± 2% | t(69) = 4.433, p < 0.001 | |
| Holeboard | Immobility time | 533 ± 12 s | 354 ± 18 s | t(64) = 7.836, p < 0.001 |
| Distance | 3586 ± 93 cm | 7492 ± 649 cm | t(64) = 5.446, p < 0.001 | |
| Rearing (number) | 246 ± 10 | 246 ± 13 | t(64) = 0.011, p = 0.992 | |
| Rearing (duration) | 362 ± 20 s | 239 ± 16 s | t(64) = 4.876, p < 0.001 | |
| Nose pokes | 33 ± 3 | 32 ± 2 | t(64) = 0.374, p = 0.709 | |
| Nose pokes (duration) | 21 ± 2 s | 17 ± 1 s | t(64) = 1.715, p = 0.091 | |
| Light-dark | Time in light | 31 ± 2% | 35 ± 2% | t(69) = 1.180, p = 0.242 |
| Light entries | 42 ± 1% | 42 ± 1% | t(69) = 0.149, p = 0.882 | |
| Startle responses | Background | 17 ± 1mV | 17 ± 1mV | Two-Way ANOVA: |
| 75dB | 34 ± 4mV | 33 ± 2mV | – intensity × treatment | |
| 90dB | 58 ± 11mV | 57 ± 8mV | F(4, 280) = 0.733, | |
| 105dB | 264 ± 29mV | 277 ± 27mV | p = 0.990 – Treatment | |
| 115dB | 393 ± 28mV | 392 ± 34mV | F(1, 70) = 0.012, p = 0.915 |
Data are shown as mean ± SEM of n = 33 Veh and n = 38 IA mice deriving from all three batches (P-Pr, F-Fr, R-Fr).
p values ≤ 0.05 are accepted as significant and written in bold.