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editorial
. 2012 Dec 26;4(12):312–326. doi: 10.4330/wjc.v4.i12.312

Table 1.

Summary of endothelial progenitor cell levels in different disease populations

Disease Results Comments Ref.
Aging ↓ EPCs proliferation [20,22]
↓ EPCs migration
↓ EPCs survival
Coronary heart disease ↓ EPC activity [29]
↓ EPC migratory capacity
CHF ↑ EPC levels in mild stages[34,35] [34-36]
↑ EPC levels in acute exacerbation[36]
↑ Late apoptotic progenitors[35]
↓ EPC levels in advanced stages[34,35]
LVADs ↑ EPC levels [38,39]
PAH ↑ EPC levels[42,45,46] Conflicting results [42-46]
↓ EPC levels[43,44]
Critical illness ↑ EPC levels in sepsis and septic shock[47,49] [47-49]
↑ EPC levels in early acute lung injury[48]
COPD ↑ EPC levels[52] Conflicting results [52-56]
↓ EPC levels[53,54]
↑ EPC levels in exacerbation of COPD[55]
↓ EPC mobilization and colony-forming capacity[56]
OSA ↑ EPC levels[58,60] Conflicting results [57-60]
↓ EPC levels[59]
- No difference[57]
Diabetes mellitus type Iand II ↓ EPC levels [61-65]
Cerebrovascular disease ↓ EPC levels in stroke[66] [66-69]
- No difference in ischemic stroke[67]
↑ EPC levels in acute ischemic stroke[67]
↓ EPC levels in atherothrombotic cerebral ischemic event[68]
↓ EPC colony forming in acute stroke[69]
PAD ↑ EPC levels in moderate phase [71,72]
↑ EPC levels in advance phase
Arterial hypertension ↑ EPC levels in early stage of hypertension[73] [19,73,74]
↓ EPC migratory capacity in CAD and hypertension[19]
- No difference on EPC levels in pre-hypertensive and hypertensive[74]
Obesity ↓ EPC levels[75-77] [75-79]
↓ EPC colony forming capacity[76]

EPC: Endothelial progenitor cell; CHF: Chronic heart failure; LVAD: Left ventricular assist device; PAH: Pulmonary arterial hypertension; COPD: Chronic obstructive pulmonary disease; OSA: Obstructive sleep apnea; PAD: Peripheral arterial disease; CAD: Coronary artery disease.