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. Author manuscript; available in PMC: 2012 Dec 27.
Published in final edited form as: Nature. 2012 Jul 12;487(7406):244–248. doi: 10.1038/nature11126

Figure 4. Loss of eIF5A andAMD1 cooperate in lymphoma progression.

Figure 4

a, Deletions of eIF5A (17p) and AMD1 (6q21) are significantly associated in human lymphoma. Red lines identify significant pairwise co-deletion frequency for the indicated genomic regions. Representative tumour suppressors are shown. b, Outline of the two-colour in vivo cooperation assay. c, Survival curves for the following shRNA combinations: GFP–Ren + Cherry–Luc (n = 10, black); GFP–Eif5a + Cherry–Luc (n = 15, blue); GFP–Ren + Cherry-Amd1 (n = 15, red); GFP–Eif5a + Cherry–Amd (n = 20, orange). P values refer to Mantel–Cox tests of the Eif5a–Amd1 knockdown versus Eif5a + Luc or Ren + Amd1. Bright-field (BF), GFP and Cherry imaging (d) and flow cytometry (e) for the indicated shRNA combinations. The first shRNA was tagged with GFP, the second with Cherry.