Table 4.
LD30, LD50 and LD70 estimates from C57BL/6 and CBA/Ca mice exposed to partial- body irradiation (40% bone marrow shielding and receiving post-irradiation antibiotic support (ciprofloxacin). The predicted lethal dose needed to deliver an LD30, LD50 and LD70 are shown, along with the lower and upper confidence limits for these figures, for days 6, 7, 8 and 20.
| C57BL/6 | CBA/Ca | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Group | Day | LD | Dose (Gy) |
Lower 95% CI |
Upper 95% CI |
Group | Day | LD | Dose (Gy) |
Lower 95% CI |
Upper 95% CI |
|
PBI BM40 +
Cipro (240) |
6 | 30 | 15.4 | 15.0 | 15.8 |
PBI BM40 +
Cipro (180) |
6 | 30 | 15.6 | 15.0 | 16.3 |
|
PBI BM40 +
Cipro (240) |
6 | 50 | 16.1 | 15.6 | 16.6 |
PBI BM40 +
Cipro (180) |
6 | 50 | 16.5 | 15.5 | 17.5 |
|
PBI BM40 +
Cipro (240) |
6 | 70 | 16.7 | 16.0 | 17.5 |
PBI BM40 +
Cipro (180) |
6 | 70 | 17.3 | 15.9 | 18.9 |
|
PBI BM40 +
Cipro (240) |
7 | 30 | 15.2 | 14.8 | 15.6 |
PBI BM40 +
Cipro (180) |
7 | 30 | 15.0 | 14.5 | 15.4 |
|
PBI BM40 +
Cipro (240) |
7 | 50 | 15.8 | 15.3 | 16.3 |
PBI BM40 +
Cipro (180) |
7 | 50 | 15.7 | 15.1 | 16.2 |
|
PBI BM40 +
Cipro (240) |
7 | 70 | 16.5 | 15.8 | 17.1 |
PBI BM40 +
Cipro (180) |
7 | 70 | 16.4 | 15.6 | 17.2 |
|
PBI BM40 +
Cipro (240) |
8 | 30 | 14.6 | 14.3 | 15.0 |
PBI BM40 +
Cipro (180) |
8 | 30 | 14.9 | 14.5 | 15.4 |
|
PBI BM40 +
Cipro (240) |
8 | 50 | 15.2 | 14.9 | 15.6 |
PBI BM40 +
Cipro (180) |
8 | 50 | 15.6 | 15.1 | 16.1 |
|
PBI BM40 +
Cipro (240) |
8 | 70 | 15.9 | 15.4 | 16.4 |
PBI BM40 +
Cipro (180) |
8 | 70 | 16.2 | 15.5 | 17.0 |
|
PBI BM40 +
Cipro (240) |
20 | 30 | 14.2 | 13.9 | 14.6 |
PBI BM40 +
Cipro (180) |
20 | 30 | 14.9 | 14.5 | 15.4 |
|
PBI BM40 +
Cipro (240) |
20 | 50 | 14.8 | 14.5 | 15.2 |
PBI BM40 +
Cipro (180) |
20 | 50 | 15.6 | 15.1 | 16.1 |
|
PBI BM40 +
Cipro (240) |
20 | 70 | 15.5 | 15.0 | 15.9 |
PBI BM40 +
Cipro (180) |
20 | 70 | 16.2 | 15.5 | 17.0 |