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. Author manuscript; available in PMC: 2012 Dec 27.
Published in final edited form as: J Cell Physiol. 2008 Dec;217(3):752–758. doi: 10.1002/jcp.21550

Figure 4. PAK1 is a MEK-Independent Raf Target.

Figure 4

(A) PAK1 functions downstream of Raf. Day 4 mature osteoclasts were infected with vector, caPAK1, dnRaf, or caPAK1 and dnRaf adenoviruses for 18 hours. Following infection, osteoclasts were serum starved and treated with 25 ng/ml M-CSF for eight hours. Shown are Percent Apoptotic Osteoclasts. (B) PAK1 and MEK have separate functions. Day 4 mature osteoclasts were infected with vector, caMEK, dnPAK1, or caMEK and dnPAK1 adenoviruses for eighteen hours. Following infection, osteoclasts were serum starved and treated with M-CSF for eight hours. Shown are Percent Apoptotic Osteoclasts. *p<0.05 compared to vector infection.