TABLE 1.
MdeA confers resistance to a range of antimicrobial agents.
| Compound | MIC (μg/ml)
|
||
|---|---|---|---|
| RN4220 (pYH4) | RN4220 (pYH4-MdeA) | RN4220 (pYH4-NorA) | |
| Ethidium bromide | 4 | 64 | ≥128 |
| Benzalkonium chloride | 1 | 4 | 8 |
| Dequalinium chloride | 1 | 2 | 8 |
| Pentamidine isethionate | 16 | 16 | ≥256 |
| Virginiamycin | 0.5 | 8 | 0.5 |
| Novobiocin | 0.13 | 1 | 0.5 |
| Mupirocin | 0.03 | 0.5 | 0.06 |
| Fusidic acid | 0.06 | 0.25 | 0.13 |
| Norfloxacin | 0.5 | 0.5 | 32 |
.
Values tabulated are MICs in micrograms per milliliter and are the averages of three determinations. In addition, MdeA did not confer significant resistance to the following antibacterials: bacitracin, ceftazidime, chloramphenicol, erythromycin, gentamicin, imipenem, kanamycin, linezolid, oxacillin, phosphomycin, piperacillin, streptomycin, tetracycline, tiamulin, trimethoprim, vancomycin, ciprofloxacin, levofloxacin, gatifloxacin, tosufloxacin, grepafloxacin, sparfloxacin, and moxifloxacin.