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. 2012 Aug 30;33(24):3023–3033. doi: 10.1093/eurheartj/ehs275

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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2012.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Histological, histochemical, and ultrastructural features of mitochondrial DNA-related cardiomyopathy. (A) Histological examination of explanted left ventricular tissue from a patient with a homoplasmic mt-tRNA^Ile mutation reveals enlarged cardiomyocytes with prominent cytoplasmic vacuolization (H&E, 20×). (B) Vacuoles contain lipid droplets that stain with Oil Red O (40×). (C) Sequential cytochrome c oxidase/succinate dehydrogenase histochemistry shows several cytochrome c oxidase-deficient cardiomyocytes (blue) with scattered cytochrome c oxidase-positive cells (brown, 40×). (D) Ultrastructural analysis reveals proliferation of polymorphic mitochondria and displacement of sarcomeres (uracyl acetate lead citrate, 3150×).