Table 2.
Effects of Phenobarbital administration prior to initiation of therapeutic hypothermia on the profile of the esophageal temperature (Te) during the induction phase.
| No Phenobarbital (N=54) | Phenobarbital (N=44) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean | SD | Q1 | Median | Q3 | Mean | SD | Q1 | Median | Q3 | |
| Time to surpass 33.5°C (hours) † | 0.99 | 0.51 | 0.75 | 1.00 | 1.25 | 0.77 | 0.39 | 0.50 | 0.75 | 0.75 |
| Time to reach the minimum Te below 33.5°C (hours) † | 1.43 | 0.93 | 1.00 | 1.25 | 1.50 | 1.24 | 1.15 | 0.75 | 1.00 | 1.25 |
| Minimum temperature below the target (°C) | 32.2 | 0.5 | 31.8 | 32.2 | 32.5 | 32.1 | 0.7 | 31.7 | 32.1 | 32.4 |
| Depth of minimum Te below 33.5°C (°C) | 1.3 | 0.5 | 1.00 | 1.3 | 1.7 | 1.4 | 0.7 | 1.1 | 1.4 | 1.8 |
| Time to stabilize Te at 33.5°C after overshoot (hours) | 1.53 | 3.12 | 0.50 | 1.00 | 1.25 | 2.34 | 4.25 | 0.75 | 1.00 | 1.75 |
| Duration of induction, from initiation of cooling (hours) | 2.96 | 3.80 | 2.00 | 2.25 | 2.75 | 3.60 | 4.78 | 1.75 | 2.00 | 2.75 |
†
p≤0.01 (Wilcoxon two-sample test, t approximation).