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. Author manuscript; available in PMC: 2012 Dec 27.
Published in final edited form as: Bioorg Med Chem. 2010 Jun 18;18(15):5576–5592. doi: 10.1016/j.bmc.2010.06.038

Scheme 1.

Scheme 1

Synthesis of focused libraries of PI-083 using commercially available building blocks. Reagents and conditions: a (i) when R2, R3 = Cl, 95% EtOH, reflux at 115°C, 3 days. (ii) when R2 = Me, R3 = H, anhydrous dioxane, 10% ytterbium triflate, 125°C, 3 days. (iii) when R2, R3 = H, 90% EtOH, reflux, 3 days. b appropriate amine, EtOH, microwave, 140°C, 20 min.