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. Author manuscript; available in PMC: 2012 Dec 27.
Published in final edited form as: Bioorg Med Chem. 2010 Jun 18;18(15):5576–5592. doi: 10.1016/j.bmc.2010.06.038

Scheme 2.

Scheme 2

Reagents and conditions: a NaBH3CN, AcOH, MeOH, 0 °C-r.t., 1–2 h, b 95% EtOH, sealed tube, reflux, 115°C, 3 days. c (i) RBr (or RI), DIPEA, DMF, microwave 160 °C, 15 min. or (ii) RI, DIPEA, DMF, Ar, , r.t., 4–24 h. d DMF/MeOH (4:1, 0.2 g in 30 mL), H-cube H2, 10% Pd/C, 40 bar, r.t., flow rate = 1.0 mL/min