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. Author manuscript; available in PMC: 2013 Mar 7.
Published in final edited form as: J Med Chem. 2012 Feb 14;55(5):1978–1998. doi: 10.1021/jm201118h

Figure 4.

Figure 4

Effects of compound 39 on proteasomal CT-L activity, ubiquitination and tumor cell viability in human breast cancer MDA-MB-468 cells. Exponentially growing human breast cancer cells were treated with different concentrations of compound 39 for 11 hr, followed by measurement of CT-L activity in whole cell extracts (A), determination of ubiquitination by Western blot analysis (B) and cell viability as measured by MTT assay (C).