Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Synthesis of hydronaphthoquinone sulfonamide scaffold
Reagents and conditions: a) thiophene-2-sulfonyl chloride, Et3N, dichloromethane, r.t., 14 h, 90%; b) for 4a (i) H2O2 (35%), CH3OH, r.t., 2 hrs, (ii) 4M HCl/dioxane, r.t., 2 h, 22%; for 4b Br2, Et3N, DMF, 0 °C to r.t., 12–14 h, 36 % and for 4c I2, Et3N, DMF, 0 °C to r.t., 12 h, 100%.
