FIG. 2.

Effects of cyclosporine (10 mg/kg) and probenecid (50 mg/kg) on the biliary clearance and steady-state concentrations of azithromycin in plasma. The overall mean values of biliary clearance of azithromycin in control rats and cyclosporine- and probenecid-treated rats were 1.49, 0.05, and 0.40 ml/min, respectively. The data are the mean means ± the standard errors (n = 5 to 6). At the time point indicated by the arrow, cyclosporine or probenecid was administered intravenously. “a” indicates values that are significantly different from the control values (P < 0.05).