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. 2012 Dec 14;55(24):10948–10957. doi: 10.1021/jm301328h

Table 6. The Stability and Plasma Protein Binding Data of Five Selected Compoundsa.

cmpd microsomal stability (mL/min/g) plasma protein binding (% bound) EC50 (μM) CC50 (μM)
84 6 94.1 0.028 29
57 1.9 92.0 0.29 >50
60 3 81.2 0.24 >50
63 0.5 52.3 0.34 >50
66 1.8 90.5 0.24 43.6
a

Reference compound: chloroquine EC50 = 0.007 μM.