TABLE 2.

Estimated APV and GW433908 free acid pharmacokinetic parameters (in the portal vein) after administration of single oral doses of GW433908 calcium salt to portal vein-cannulated Han Wistar rats and a beagle dog

Parameter	Speciesa
	Ratb		Dog
	APV	GW433908	APV	GW433908
AUC0-∞ (h · μg/ml)	44.6	0.156c	8.60	0.0848
Cmax (μg/ml)	7.00	0.0637	6.00	0.120
Tmax (h)	2.0	0.5	0.5	0.25
t1/2 (h)	1.6	NDe	0.5	0.4
AUC ratiod (GW433908/APV)	0.003		0.0085
Cmax ratiod (GW433908/APV)	0.0079		0.0172

^aGW433908 dose: 112 mg/kg in rat and 35 mg/kg in dog.

^bValues for rats are composite means.

^cAUC₂₄.

^dMolar basis.

^eND, not determined.