TABLE 3.
GW433908 and APV amounts in apical or basolateral compartments following application of GW433908 to Caco-2 monolayers
| Applied dose (μM) for side | Amt (nmol) in compartment analyzeda
|
|||
|---|---|---|---|---|
| Apical
|
Basolateral
|
|||
| GW433908 | APV | GW433908 | APV | |
| Apical | ||||
| 10 | 2.4 ± 0.2 | 0.44 ± 0.04 | <0.008 | 0.01 ± 0.01 |
| 100 | 40 ± 1.7 | 9.4 ± 0.2 | <0.008 | 0.4 ± 0.1 |
| Basolateral | ||||
| 10 | <0.002 | 0.11 ± 0.01 | 11.4 ± 0.8 | 0.03 ± 0.01 |
| 100 | 0.01 ± 0.01 | 0.3 ± 0.03 | 204 ± 8 | 1.0 ± 0.1 |
a
Values are the means ± standard deviations of three individual cell monolayers.