Table 2.
Post-transplant outcomes
| Pt | Non-relapse/non- GVHD toxicity | Acute GVHD (Grade, Organ, and Stage) | Chronic GVHD | Disease Status at 100 days | Relapse (Y/N) | Treatment(s) since relapse | Current status | Time SCT to last follow up (months) |
|---|---|---|---|---|---|---|---|---|
| 1 | CNS PTLD (responded to Rituximab), CMV antigenemia, Pneumonitis | - | - | CR | Y | Denileukin Diftitox, Alemtuzumab | Expired (progression) | 37 |
| 2 | Widely metastatic melanoma* | Grade II (Gut Stage 1) | - | CR | Y | - | Expired (progression and metastatic melanoma)* | 7 |
| 3 | Sinusitis, Osteoporosis, Herniated disk, Hearing loss, Steroid-induced glaucoma | Grade III (Gut Stage 3) | Severe chronic GVHD of Mouth, Musculoskeletal system and Lungs (Bronchiolitis obliterans) | CR | N | - | Alive, CR (continuous) | 45 |
| 4 | Steroid-induced DM | Grade II (Skin Stage 3, Gut Stage 1, Liver Stage 0) | - | CR | Y | DLI with re-achievement of CR. | Alive, CR | 39 |
| 5 | Bacterial sepsis | - | - | Expired | Y | - | Expired (Early TRM) | 2 |
| 6 | - | Grade III (Skin Stage 3, Liver Stage 2) | - | Prog-ression | Y | Tapering of immunosuppression (not effective), nodal XRT, Cyclophosphamide | Expired (progression) | 5 |
| 7 | - | Grade I (Skin Stage 1) | - | Relapse | Y | Tapering of immunosuppression, DLI (ineffective), Vorinostat, Topical carmustine, TSEB, Interferon gamma-1b, ICE | Alive, Active disease (chemo-responsive) | 27 |
| 8 | PICC-associated UE DVT, hypothyroidism, Herpes zoster | Grade III (Skin Stage 3, Liver Stage 0) | - | CR | N | - | Alive, CR (continuous) | 22 |
| 9 | Cholecystitis, bacterial sepsis | Grade IV (Gut Stage 4, Liver Stage 4-VOD) | - | CR | N | - | Expired in CR (GVHD) | 6 |
| 10 | Bacterial sepsis | Grade I (Skin Stage 2) | - | Expired | Y | - | Expired (Early TRM) | 1 |
| 11 | Hypothyroidism | - | - | CR | N | - | Alive, CR (continuous) | 16 |
| 12 | - | Grade I (Skin Stage 2) | - | CR | Y | Tapering of immunosuppression with re-achievement of CR | Alive, CR | 13 |
*
Patient #2 had a remote history of localized, resected melanoma, which resurfaced as widely metastatic disease after HSCT. Death was due to rapid progression of both CTCL and melanoma.
CMV: Cytomegalovirus
DVT: Deep Venous Thrombosis
ICE: Ifosfamide, Carboplatin, Etoposide
PTLD: Post-Transplant Lymphoproliferative Disease
TRM: Transplant Related Mortality
VOD: Veno-Occlusive Disease