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When cocaine was self-administered under a progressive ratio schedule, there were no differences between the breakpoints of female CocSired and SalSired rats at either cocaine dose (a). The breakpoint for 1.0 mg/kg cocaine was significantly reduced in male cocaine-sired relative to saline-sired (♂SalSired) rats (b). Data are expressed as the mean (±s.e.m.) lever presses per session. The asterisks represent significant differences between the SalSired and CocSired groups (p<0.05).
