TABLE 1.
MICs of each antibiotic alone and time-kill results for the eight clinical A. baumannii isolates
| A. baumannii isolate | MIC (μg/ml)
|
Time (h) and antibacterial effecta
|
||||
|---|---|---|---|---|---|---|
| IPM | PB | RIF | IPM+PB+RIF | IPM+PB | PB+RIF | |
| A | 32 | 1 | 2 | 2, bactericidal | 4, bactericidal | 8, regrowth |
| B | 32 | 1 | 2 | 4, bactericidal | 2, bactericidal | 2, bactericidal |
| C | >32 | 2 | 8 | 2, bactericidal | 8, bactericidal | 8, bactericidal |
| D | >32 | 2 | 12 | 4, bactericidal | 24, bactericidal | 8, bactericidal |
| E | >32 | 1 | 5 | 8, bactericidal | 2, regrowth | 24, bactericidal |
| F | >32 | 1 | 5 | 8, bactericidal | 8, bactericidal | 24, bactericidal |
| G | >32 | 8 | 1 | 8, bactericidal | 8, bactericidal | 24, bactericidal |
| H | >32 | 1.5 | >32 | 24, bactericidal | 8, bactericidal | 24, bactericidal |
a
Time-kill results are for experiments using double and triple combinations of imipenem (IPM), polymyxin B (PB), and rifampin (RIF) at 8, 0.25, and 0.5 μg/ml, respectively.