Figure 3.
The anchor patterns and interacting residues of the kinases ABL1, MAPK14, EPHA7 and FES. (A) The partial anchor patterns of the ABL1-nilotinib family. The kinase groups are labeled in parentheses with the corresponding kinase names. (B) The partial anchor patterns of EPHA7 and FES, which are not members of the ABL1-nilotinib family. (C) Residues, pocket surfaces and nilotinib reference poses of ABL1, MAPK14, EPHA7 and FES using the ABL1-nilotinib structure (PDB code 3CS9). (D) Superimposed structures. (E) Residues of ABL1, MAPK14, EPHA7 and FES.