Figure 1.

PhyloView of the paired-like homeobox 2b (PHOX2B) gene in human, the reference gene and reference species for this display, rooted at the Euteleostomi ancestor. This region is remarkably well conserved in the descendants of the ancestral Euteleostomi. PHOX2B is surrounded by a high density of conserved CNEs identified between human and several mammals (green and orange symbols), but also with chicken (red symbols) and fish (blue symbols). To obtain this specific display, the user should (i) query the Genomicus vertebrate server with the human PHOX2B gene; (ii) in the resulting PhyloView display, select ‘View’ and ‘change root species’ to restrict the display to Euteleostomi (89 homologues); (iii) zoom in once to obtain only six genes on each side of the reference gene; (iv) tick the CNE track box in the ‘View’ menu; and (v) hide (e.g. elephant) or collapse (e.g. smegmamorpha) specific species or phylum using the red cross that appears by mouse-over on the corresponding node (to hide) or by directly clicking on the corresponding node (to collapse).