Figure 2.
Network visualization and statistical analysis of a user-supplied protein list. The STRING screenshot shows a user-supplied set of genes, here a selection of cancer genes as annotated at the COSMIC database (52). The set is restricted to those genes that are known to pre-dispose to cancer already when mutated in the germline, and that have at least one connection in STRING. The inset illustrates the website’s new functionality for automatically detecting statistically enriched functions or processes in a network. In this example, one of the detected processes (nucleotide excision repair) is of interest and has been selected; STRING automatically highlighted the corresponding nodes in the network, where they are seen to form a densely connected module.