Figure 3.

APPRIS result for gene TP63. (A) The four variants of gene TP63 that score highest in APPRIS, highlighting the 5′-splice junction differences between TA and P63delta, deltaN and TP63-013, and the GYNGYN splice event that differentiates TA and deltaN from P63delta and TP63-013. (B) Annotation results from some of the individual modules in APPRIS (Matador3D maps 3D structure to the isoforms, SPADE maps Pfam functional domains and CORSAIR detects orthologous isoforms in related species). The isoforms are color-coded as in (A) and we have added two other well-known TP63 variants to the table. APPRIS chooses isoform TP63-013 as the main variant based on the output of the three modules.