TABLE 3.
Inhibition of C. albicans germ tube formation by the furanone derivatives
| Antifungal compound | % Formation of germ tubes by C. albicans straina:
|
|||
|---|---|---|---|---|
| 4 | 5 | 7 | 8 | |
| LNO6-22 | 1.7 ± 0.9 | 1.7 ± 0.5 | 1.3 ± 1.2 | 3.0 ± 1.6 |
| LNO15-22 | 58.7 ± 2.9 | 30.0 ± 2.2 | 5.7 ± 1.2 | 30.3 ± 2.1 |
| LNO18-22 | 70.3 ± 3.7 | 62.7 ± 3.1 | 6.7 ± 1.2 | 75.0 ± 4.5 |
| Amphotericin B | 1.0 ± 0.8 | 2.0 ± 1.6 | 0.3 ± 0.5 | 1.0 ± 0.8 |
| Fluconazole | 74.3 ± 1.7 | 51.0 ± 2.2 | 29.7 ± 2.5 | 98.0 ± 0.8 |
| Control | 88.5 ± 5.3 | 78.5 ± 17.3 | 57.8 ± 8.9 | 95.0 ± 2.1 |
| Control with DMSOb | 87.8 ± 12.5 | 79.3 ± 14.8 | 49.8 ± 22.6 | 97.5 ± 2.2 |
a
Strain numbers correspond to CA4, CA5, CA7, and CA8 in Fig. 2. Values for strains 4 and 5 are shown with standard deviations. All values are geometric means of three experiments and were obtained at MIC/10.
b
Control (NYP medium) with 1% DMSO.