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. 2004 Mar;48(3):728–738. doi: 10.1128/AAC.48.3.728-738.2004

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FIG. 7. — Competition assay with mannopeptimycins. (A) TLC assay. The assay was done essentially as described in the legend to Fig. 6B. Prior to the addition of [³H]AC98-3189, the samples were supplied and preincubated with various mannopeptimycins, as indicated. (B) Quantitative analysis of TLC assay. Shown are a graph derived from densitometry analysis of spots that correspond to putative [³H]AC98-3189-lipid II complex (A) and a comparison of the 50% inhibitory concentrations (IC₅₀s) versus the MICs of various mannopeptimycins. A log scale is used for the compound concentration. (C) Effect of AC98-6446 on binding of [³H]AC98-3189 to membrane components. Shown is a comparison of the competition effects of AC98-6446 on the amount of both putative [³H]AC98-3189-lipid II complex and [³H]AC98-3189 that was retained on the TLC baseline.