Table 2.
Results of group comparisons of ALS patients versus controls
| Side | Cluster size | x | y | z | T | p | |
|---|---|---|---|---|---|---|---|
|
T0 FA all ALS patients (n=24) < controls |
|
|
|
|
|
|
|
| Corpus Callosum |
l |
7954 |
-10 |
-14 |
29 |
6.03 |
0.002 |
| Corpus Callosum |
l |
|
-1 |
-16 |
25 |
5.35 |
0.003 |
| Corpus Callosum |
r |
|
11 |
-16 |
29 |
5.29 |
0.003 |
| Brainstem, Pons, CST |
l |
1589 |
-8 |
-27 |
-34 |
5.82 |
0.002 |
| Brainstem, Pons, CST |
r |
|
9 |
-26 |
-36 |
4.54 |
0.007 |
| Brainstem, Pons, CST |
r |
|
10 |
-22 |
-24 |
3.88 |
0.027 |
| Precentral Gyrus, WM |
r |
2386 |
14 |
-21 |
58 |
5.69 |
0.002 |
| subgyral, WM, Corona Radiata |
r |
|
27 |
-38 |
50 |
4.02 |
0.021 |
| Medial Frontal Gyrus, WM, below BA 6 |
l |
743 |
-12 |
-13 |
70 |
5.03 |
0.003 |
| Precentral Gyrus, WM |
r |
290 |
48 |
4 |
8 |
4.59 |
0.007 |
| Corona Radiata, Medial Frontal Gyrus, below BA 6 |
l |
687 |
-35 |
-12 |
48 |
4.37 |
0.01 |
| Precentral Gyrus, WM |
l |
|
-39 |
-19 |
48 |
4.18 |
0.015 |
| subgyral, WM, below Gyrus postcentralis |
l |
201 |
-10 |
-37 |
61 |
4.35 |
0.011 |
| Precentral Gyrus, subgyral, WM, Corona Radiata |
l |
343 |
-42 |
-15 |
23 |
4.34 |
0.011 |
| Precentral Gyrus, WM |
l |
942 |
-28 |
-24 |
55 |
4.26 |
0.013 |
| Frontal Lobe, subgyral, WM, Corona radiata |
l |
|
-17 |
-24 |
55 |
3.62 |
0.042 |
| Frontal Lobe, subgyral, WM, Corona radiata |
r |
345 |
33 |
-8 |
38 |
3.87 |
0.028 |
| Frontal Lobe, Precentral Gyrus, WM, Corona radiata |
l |
309 |
-39 |
-6 |
35 |
3.86 |
0.028 |
| Frontal Lobe, Precentral Gyrus, BA 6 |
l |
|
-46 |
1 |
40 |
3.82 |
0.03 |
| Limbic Lobe, Parahippocampal Gyrus, WM |
l |
218 |
-20 |
-48 |
-11 |
3.80 |
0.032 |
|
T0 ADC all ALS patients (n =24) > controls |
|
|
|
|
|
|
|
| Precentral Gyrus, WM |
l |
5108 |
-9 |
-25 |
67 |
5.99 |
0.02 |
| Precentral Gyrus, subgyral, WM, below BA 6 |
l |
|
-28 |
-16 |
65 |
5.5 |
0.02 |
| Frontal Lobe, subgyral, WM, Corona radiata |
l |
|
-28 |
-25 |
50 |
5.33 |
0.02 |
| Precentral Gyrus, subgyral, WM |
r |
5537 |
21 |
-16 |
65 |
5.56 |
0.02 |
| Precentral Gyrus, WM |
r |
|
11 |
-23 |
67 |
5.22 |
0.02 |
| Frontal Lobe, subgyral, WM, Postcentral Gyrus |
r |
|
15 |
-34 |
61 |
4.31 |
0.031 |
| Brainstem, Pons |
r |
3243 |
6 |
-22 |
-28 |
5.13 |
0.02 |
| Brainstem, Pons |
l |
|
-4 |
-23 |
-28 |
4.21 |
0.034 |
| Limbic Lobe, Parahippocampal Gyrus, WM |
r |
|
26 |
-14 |
-14 |
3.98 |
0.041 |
| Temporal Lobe, Superior Temporal Gyrus, GM |
l |
547 |
-62 |
-12 |
-1 |
4.90 |
0.02 |
| Parietal Lobe, Superior Parietal Lobule, subgyral, BA 7 |
r |
754 |
21 |
-50 |
65 |
4.73 |
0.022 |
| Precentral Gyrus, WM |
r |
336 |
47 |
-2 |
31 |
4.55 |
0.025 |
| Postcentral Gyrus, subgyral, WM |
l |
645 |
-18 |
-32 |
71 |
4.22 |
0.034 |
| Postcentral Gyrus, subgyral, WM |
l |
|
-27 |
-31 |
67 |
4.02 |
0.04 |
| Frontal Lobe, Superior Frontal Gyrus, GM, BA 9 |
l |
467 |
-22 |
42 |
39 |
4.15 |
0.036 |
| Frontal Lobe, subgyral, WM |
l |
|
-25 |
39 |
29 |
3.78 |
0.046 |
| Temporal Lobe, subgyral, WM |
l |
409 |
-32 |
9 |
-35 |
4.11 |
0.037 |
| Frontal Lobe, Superior Frontal Gyrus, WM |
r |
269 |
5 |
20 |
53 |
4.02 |
0.04 |
| Frontal Lobe, Medial Frontal Gyrus, GM, BA 8 |
l |
383 |
-6 |
27 |
53 |
4.02 |
0.04 |
| Limbic Lobe, Uncus, WM |
r |
827 |
22 |
-3 |
-36 |
3.95 |
0.041 |
| Limbic Lobe |
r |
|
22 |
-8 |
-43 |
3.68 |
0.049 |
| Frontal Lobe, Precentral Gyrus, subgyral, WM |
l |
231 |
-51 |
-3 |
23 |
3.91 |
0.042 |
| Sub-lobar, Insula, WM |
l |
208 |
-40 |
-17 |
19 |
3.89 |
0.043 |
| Frontal Lobe, Superior Frontal Gyrus, GM |
l |
233 |
-22 |
10 |
57 |
3.88 |
0.043 |
| Frontal Lobe, Middle Frontal Gyrus, GM, BA 8 |
l |
217 |
-23 |
20 |
50 |
3.87 |
0.043 |
| Frontal Lobe, Middle Frontal Gyrus, GM, BA 10 |
r |
365 |
27 |
53 |
26 |
3.81 |
0.045 |
| Frontal Lobe, Superior Frontal Gyrus, GM, BA 9 |
r |
|
24 |
45 |
39 |
3.71 |
0.048 |
|
Follow-up FA all ALS patients (n =15) < controls |
|
|
|
|
|
|
|
| Precentral Gyrus, subgyral, WM, Corona radiata |
r |
293 |
48 |
4 |
6 |
6.26 |
0.017 |
| Corpus Callosum |
l |
3260 |
-8 |
-18 |
28 |
5.70 |
0.017 |
| Corpus Callosum |
r |
|
11 |
-17 |
28 |
4.8 |
0.026 |
| Left Brainstem, Pons |
l |
218 |
-6 |
-28 |
-38 |
5.02 |
0.02 |
| Limbic Lobe, Parahippocampal Gyrus, WM |
l |
1004 |
-22 |
-42 |
-10 |
4.89 |
0.023 |
| Temporal Lobe, Fusiform Gyrus, GM, BA 37 |
l |
|
-27 |
-37 |
-16 |
4.26 |
0.04 |
| Sub-lobar, Thalamus, GM, Pulvinar |
l |
217 |
-13 |
-33 |
1 |
4.51 |
0.033 |
| Frontal Lobe, Medial Frontal Gyrus, WM, Corona radiata |
r |
696 |
13 |
-26 |
58 |
4.44 |
0.035 |
| Frontal Lobe, Medial Frontal Gyrus, WM, Corona radiata |
r |
|
9 |
-27 |
69 |
4.28 |
0.04 |
| parahippocampal Amygdala |
r |
206 |
29 |
-30 |
-26 |
4.36 |
0.037 |
| Limbic Lobe, Parahippocampal Gyrus, GM, BA 34 |
r |
204 |
17 |
-7 |
-19 |
4.20 |
0.043 |
|
Follow-up ADC all ALS patients (n =15) > controls |
|
|
|
|
|
|
|
| Precentral Gyrus, WM |
r |
3258 |
24 |
-20 |
63 |
6.18 |
0.036 |
| Precentral Gyrus, subgyral, WM |
r |
|
12 |
-21 |
62 |
5.01 |
0.001* |
| Precentral Gyrus, subgyral, WM, Corona radiata |
r |
|
18 |
-20 |
43 |
4.1 |
0.013* |
| Sub-lobar, Extra-Nuclear, WM, Internal capsule, Crus post. |
r |
379 |
18 |
-13 |
-1 |
4.32 |
0.008* |
| Sub-lobar, Extra-Nuclear, WM, Internal capsule, Crus post. |
l |
1234 |
-18 |
-13 |
-2 |
4.28 |
0.009* |
| Sub-lobar, Extra-Nuclear, WM, Internal capsule, Crus post. |
l |
|
-19 |
-12 |
6 |
4.13 |
0.012* |
| Precentral Gyrus, WM |
l |
351 |
-9 |
-25 |
65 |
4.27 |
0.009* |
| Precentral Gyrus, subgyral, WM, Corona radiata |
l |
1148 |
-37 |
-11 |
43 |
4.16 |
0.011* |
| Precentral Gyrus, subgyral, WM, Corona radiata |
l |
|
-28 |
-25 |
50 |
4.16 |
0.012* |
| Precentral Gyrus, subgyral, WM, Corona radiata |
l |
|
-25 |
-22 |
42 |
4.06 |
0.012* |
| subgyral, WM, Corona radiata, below BA 6 | l | 241 | -13 | -14 | 59 | 4.08 | 0.014* |
Ordered by descending T-values. R=right; L=left, * SVC 10mm (FWE).