Table 4.

Correlations with clinical data

	Side	Cluster size	x	y	z	T	p
T0 FA correlation with ALSFRS-R
Right Brainstem, Midbrain	r	233	10	-24	-21	4.41	0.019*
Cerebellum, Posterior Lobe, Declive	r	251	13	-58	-19	3.99	0.04*
T0 FA correlation with disease duration
Precentral Gyrus, WM, below BA 6	r	596	4	-27	70	4.93	0.007*
Precentral Gyrus, subgyral, WM, Corona radiata	r		6	-30	61	4.52	0.014*
Sub-lobar, WM, CST, Internal capsule	l	867	-31	-26	17	4.58	0.013*
Sub-lobar, WM, CST, Internal capsule	l		-30	-18	15	4.47	0.017*
Cerebellum, Anterior Lobe, Culmen	r	317	12	-56	-15	4.56	0.014*
Sub-lobar, WM, CST, Corona radiata	l	202	-13	-29	51	4.37	0.02*
T0 FA correlation with SF36
Cerebellum, Anterior Lobe, Culmen	r	715	19	-43	-27	5.24	0.004*
Cerebellum, Anterior Lobe	r		10	-42	-33	4.4	0.019*
Cerebellum, Anterior Lobe	l	561	-10	-41	-33	4.84	0.008*
Cerebellum, Anterior Lobe, Culmen	l		-16	-42	-27	4.22	0.027*
Follow-up FA correlation with ALSFRS-R
Precentral Gyrus, subgyral, WM, BA 6	r	469	50	2	38	6.35	0.006*
Precentral Gyrus, subgyral, WM, BA 6	r		46	-5	46	6.11	0.008*
Frontal Lobe, Middle Frontal Gyrus, WM	r	233	33	13	50	5.99	0.01*
Precentral Gyrus, WM, Corona radiata	r	417	29	-15	56	5.87	0.011*
Precentral Gyrus, WM, Corona radiata	l	219	-16	-12	59	5.01	0.014*
Follow-up FA correlation with disease duration
Capsula Inerna, Crus post., CST	l	1722	-24	-19	2	6.87	0.003*
Sub-lobar, WM, Capsula Inerna, Crus post., CST	l		-28	-25	14	5.7
Internal capsule, Crus post., CST	r	408	24	-16	-4	5.69	0.014*
Internal capsule, Crus post., CST	r		32	-17	-5	4.12
External capsule	r	431	31	-12	10	5.61	0.015*
Follow-up FA correlation with SF36
Brainstem, Pons, CST	l	387	-11	-32	-34	5.37	0.02*

Ordered by descending T-values. R=right; L=left, * SVC 10mm (FWE).