Table 4.
Odds ratios of esophageal cancer in relation to use of anti-diabetic drugs
|
Use of anti-diabetic drugs |
Case |
Control |
Odds ratio (95% CI) |
|
|---|---|---|---|---|
| Number (%) | Model 1 | Model 2 | ||
| Insulins |
|
|
|
|
| never use |
7(12.3) |
69(31.1) |
1.00 |
1.00 |
| ever use |
50(87.7) |
153(68.9) |
3.27(1.40-7.60) |
2.58(1.08-6.15) |
| Metformin |
|
|
|
|
| never use |
5(8.77) |
43(19.4) |
1.00 |
1.00 |
| ever use |
52(91.2) |
179(80.6) |
2.34(0.87-6.24) |
2.84(0.99-8.18) |
| Sulfonylureas |
|
|
|
|
| never use |
4(7.02) |
38(17.1) |
1.00 |
1.00 |
| ever use |
53(92.9) |
184(82.9) |
2.75(0.94-8.10) |
3.80(1.16-12.5) |
| Thiazolidinediones |
|
|
|
|
| never use |
49(86.0) |
180(81.1) |
1.00 |
1.00 |
| ever use |
8(14.0) |
42(18.9) |
0.65(0.28-1.49) |
1.11(0.46-2.65) |
| Alpha-glucosidase inhibitors |
|
|
|
|
| never use |
48(84.2) |
188(84.7) |
1.00 |
1.00 |
| ever use | 9(15.8) | 34(15.3) | 1.00(0.44-2.24) | |
Model 1 was adjusted for age and sex.
Model 2 was additionally adjusted for sex, age, alcoholism, periodontal disease, esophagus ulcer, esophagus reflux, other NSAIDs and COX-2 inhibitors.