Table 1. Hinge sites of gp120 based on gp120 ternary complex ENM calculation.

M95-K98	β1-α1	Inner-outer domain interface. β-sandwich minidomain junction
M100-E102		N-terminus of α1 helix helix
P118-K121	α1- β2	Inner domain-bridging sheet boundary
Q203-C205	β3- β4	Inner domain-bridging sheet boundary
K231-T232	LA	Resides on inner domain and interacts with outer domain
V255-L260	LB	Inner domain-outer domain boundary, Phe43 cavity
I272-V275	β10- β11	Inner domain-outer domain interface.
T283-V286	β11	Inner domain-outer domain interface. Interacts with CD4.
S364-F376	β15- α3- β16	CD4 binding loop
F382-S387	β17	Phe43 cavity.
R419-K421	β19	Outer domain-bridging sheet boundary
L452-T455	β23	Outer domain-inner domain interface. Interacts with CD4.
P470-D477	β24- α5	Inner domain-outer domain boundary. Interacts with CD4.