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(A) Protein expression levels of p21, cyclin B1, CDC2, cyclin A, CDK2, cyclin D1 and cyclin E in HUVECs treated by harmine for 48 hours. (B) Expression levels of endogenous angiogenesis inhibitors TSP-1 and Bai1 in HUVECs. Protein expression level of TSP-1 was detected followed by addition of harmine for 48 hours, the mRNA levels of angiogenesis inhibitors were detected after addition of harmine for 24 hours.
