Table 1. Body Weight of Mice on Chow and High-Cholesterol Diet.

Genotype	CD(g)	HCD(g)
Ldlr −/−	19.35±5.37	22.52±3.79
Ldlr −/−;Rag-2 −/−	16.66±3.20	22.83±−3.77
Socs-1 −/−	10.61±3.25*	17.74±2.62*#

Weight of mice on chow (CD) and after high-cholesterol diet (HCD). Age-matched mice were weighted after 4 weeks of CD or HCD. Socs-1^−/− triple KO mice (Socs-1^−/−) on CD and HCD demonstrated a significantly lower weight compared to Ldlr^−/− and Ldlr^−/−;Rag-2^−/− mice. However, Socs-1^−/−triple-KO mice displayed a significant weight gain after 4 weeks of HCD compared to Socs-1^−/−triple-KO mice on CD. Data represent mean±SD, *p<0.05 vs Ldlr^−/− and Ldlr^−/−;Rag-2^−/− mice, #p<0.05 vs Socs-1^−/− triple-KO mice on CD, 13–21 mice/group.