Table 3. Cholesterol Levels after 4 Weeks of High-Cholesterol Diet.

Cholesterol levels (mg/dl)	Ldlr−/−	Ldlr−/−;Rag-2−/−	Socs-1−/−triple-KO
TC	1108	702*	1018
LDL	331	210*	296
VLDL	619	351*	515
HDL	155	142	161

Cholesterol levels after 4 weeks of high-cholesterol diet (HCD). No differences in lipoprotein fractions between age-matched Ldlr^−/− and Socs-1^−/−triple-KO mice were observed after 4 weeks of HCD. Total cholesterol levels were significantly lower in Ldlr^−/−;Rag-2^−/− mice compared to the other genotypes due to lower LDL and VLDL lipoprotein fractions. *p<0.05 vs Ldlr^−/− and Socs-1^−/−triple-KO mice, data are mean ± SD, N = 7–10 mice/group.