Table 1. Clinical and pathological features of ET cases and controls.
| Cerebellar cortex | Occipital cortex | |||||
| Western Blot Analysis | Immunohistochemistry | Western Blot Analysis | ||||
| ET | Controls | ET | Controls | ET | Controls | |
| N | 10 | 11 | 12 | 13 | 7 | 9 |
| Age at death (years) | 85.7±6.1 | 84.5±6.4 | 86.5±6.4 | 83.0±7.6 | 84.3±8.8 | 84.8±6.3 |
| Female Gender | 5 (50.0%) | 6 (54.5%) | 8 (75%) | 7 (58.3%) | 3 (42.9%) | 5 (55.6%) |
| Brain Weight (grams) | 1211±126 | 1174±145 | 1187±123 | 1231±140 | 1207±140 | 1175±157 |
| Postmortem Interval (hours) | 3.1±2.3 | 4.7±2.3 | 2.6±1.8 | 8.9±10.5A | 4.4±3.8 | 4.1±1.7 |
| Braak AD Stage | 2.0±1.2 | 2.0±1.1 | 2.5±1.2 | 1.7±1.2 | 1.6±1.0 | 2.0±1.1 |
| CERAD Plaque Score | ||||||
| 0 | 5 (50.0%) | 5 (45.5%) | 7 (58.3%) | 7 (53.8%) | 4 (57.1%) | 5 (55.6%) |
| A | 3 (30.0%) | 3 (27.3%) | 3 (25.0%) | 4 (30.8%) | 1 (14.2%) | 1 (11.1%) |
| B | 2 (20.0%) | 3 (27.3%) | 2 (16.7%) | 2 (15.3%) | 2 (28.6%) | 3 (33.3%) |
| C | 0 (0.0%) | 0 (0.0%) | 0 (8.3%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) |
| Purkinje cell counts | 7.3±2.6 | 8.5±2.2 | 6.2±0.8 | 9.0±2.6 | 7.5±2.6 | 10.2±3.4 |
| Axonal Torpedoes* | 23.9±24.8 | 4.4±2.2 | 29.8±28.1 | 3.6±2.1 | 14.9±1.4 | 2.6±1.4 |
*
p<0.05.
A
Two controls had PMI >15 hours. Median PMI in controls = 5.3 hours.