Figure 4. Effects of LCMV infection on blood and splenic cellularity in LCMV infected mice.

A) Complete blood count with differential of LCMV-13 infected mice for platelet, neutrophil, lymphocyte, eosinphil and basophil counts. FVB (n = 4) or C57BL/6 (n = 1) mice were infected with 1–2×10⁶ p.f.u. LCMV-13 and blood was taken at day 7 post-infection. Additionally, naïve FVB (n = 2) blood was collected as a reference. Counts are presented as mean +/− standard deviation. Results for FVB mice are combined from two independent experiments. B) Spleen size in FVB mice exhibits an inverse correlation with infections dose of LCMV compared to C57BL/6. C) FVB mice have reduced T cell numbers as assessed by staining with anti-CD3 antibody in spleens after LCMV-13 infection. FVB (n = 10) or C57BL/6 (n = 8) mice were infected with 1–2×10⁶ p.f.u. LCMV-13 and spleens were harvested between day 7–11 post-infection. Results are presented as mean +/− standard deviation (*, p<0.05. t-test). Similar results were found in two additional independent experiments.