Table 1. Homologies among gammaherpesvirus maintenance proteins.
Gammaherpesviruses | Viral maintenance protein homologues | Internal mRNA repeat size (bp) | Purine content of the mRNA repeats (%) | Identity of the nucleotide sequence repeat in EBNA1 with nucleotide repeats in other viral maintenance protein homologues (%) | Homology2 of the protein sequence repeat in EBNA1 with repeats in other viral maintenance protein homologues (%) |
Lymphocryptoviruses | |||||
Human herpesvirus 4 | EBNA1 | 711 | 88.1 | 100 | 100 |
Macacine herpesvirus 4 | rhEBNA1 | 141 | 78.0 | 70.2 | 46.8 |
Papiine herpesvirus 1 | baEBNA1 | 49 | 80.9 | 75.6 | 55 |
Rhadinoviruses | |||||
Human herpesvirus 8 | LANA1 CR11 | 1818 | 76.2 | 52 | 0.3 |
CR2 | 50 | 0.3 | |||
CR3 | 72 | 0.4 | |||
Macacine herpesvirus 5 | ORF73 | 1554 | 66.5 | 57.1 | 2.1 |
Saimirine herpesvirus 2 | ORF73 | 546 | 85.3 | 58.5 | 17.6 |
Macaviruses | |||||
Alcelaphine herpesvirus1 | ORF73 CR1 | 2061 | 96.6 | 56.6 | 29.5 |
CR2 | 62.6 | 0 | |||
CR3 | 74 | 50 | |||
Ovine herpesvirus 2 | ORF73 CR1 | 984 | 85.7 | 65.8 | 40.8 |
CR2 | 64 | 0 | |||
CR3 | 68.4 | 44 |
CR 1–3 designates sub-regions of internal central repeats displaying varying peptide sequences.
Homology data for protein sequences was acquired using the Strider sequence alignment program that uses the BLOSUM62 score matrix to score pairs of aligned residues [42].