Table 1. Homologies among gammaherpesvirus maintenance proteins.

Gammaherpesviruses	Viral maintenance protein homologues	Internal mRNA repeat size (bp)	Purine content of the mRNA repeats (%)	Identity of the nucleotide sequence repeat in EBNA1 with nucleotide repeats in other viral maintenance protein homologues (%)	Homology2 of the protein sequence repeat in EBNA1 with repeats in other viral maintenance protein homologues (%)
Lymphocryptoviruses
Human herpesvirus 4	EBNA1	711	88.1	100	100
Macacine herpesvirus 4	rhEBNA1	141	78.0	70.2	46.8
Papiine herpesvirus 1	baEBNA1	49	80.9	75.6	55
Rhadinoviruses
Human herpesvirus 8	LANA1 CR11	1818	76.2	52	0.3
	CR2			50	0.3
	CR3			72	0.4
Macacine herpesvirus 5	ORF73	1554	66.5	57.1	2.1
Saimirine herpesvirus 2	ORF73	546	85.3	58.5	17.6
Macaviruses
Alcelaphine herpesvirus1	ORF73 CR1	2061	96.6	56.6	29.5
	CR2			62.6	0
	CR3			74	50
Ovine herpesvirus 2	ORF73 CR1	984	85.7	65.8	40.8
	CR2			64	0
	CR3			68.4	44

¹CR 1–3 designates sub-regions of internal central repeats displaying varying peptide sequences.

²Homology data for protein sequences was acquired using the Strider sequence alignment program that uses the BLOSUM62 score matrix to score pairs of aligned residues [42].