TABLE 6.
Summary of drug interactions for the six combinations testeda
| Interaction mode | % of isolates for the following combination:
|
|||||
|---|---|---|---|---|---|---|
| CAS-5FC | VRZ-5FC | CAS-AMB | CAS-VRZ | CAS-AMB-5FC | CAS-VRZ-5FCb | |
| Synergy | 62 | 0 | 0 | 0 | 100 | 67 |
| Additivity (no interaction) | 38 | 7 | 100 | 100 | 0 | 33 |
| Antagonism | 0 | 93 | 0 | 0 | 0 | 50 |
a
MICs were determined visually as the concentration that gave 100% inhibition (VisuMIC-0). CAS, caspofungin; 5FC, flucytosine; VRZ, voriconazole; AMB, amphotericin B.
b
For this combination, different modes of interaction were detected for a given isolate, depending on the concentrations of the drugs.