TABLE 1.
Species | Resistance determinant(s) | n | Antibiotic | MIC range (μg/ml) |
---|---|---|---|---|
Staphylococcus aureus | mecA | 38 | Daptomycin | 0.03-0.5 |
Oxacillin | >8->8 | |||
Ser80Phe/Glu88Lysa | 14 | Daptomycin | 0.12-0.5 | |
Ciprofloxacin | 8->8 | |||
Ser80Phe/Ser84Leu | 13 | Daptomycin | 0.12-0.5 | |
Ciprofloxacin | 4->8 | |||
Ser80Tyr/Glu88Lys | 9 | Daptomycin | 0.12-0.5 | |
Ciprofloxacin | 8->8 | |||
Ser80Tyr/Ser84Leu | 13 | Daptomycin | 0.06-0.5 | |
Ciprofloxacin | 8->8 | |||
tetK | 18 | Daptomycin | 0.06-1 | |
tetM | 18 | Daptomycin | 0.06-0.25 | |
tetK+tetM | 7 | Daptomycin | 0.12-0.5 | |
Enterococcus faecalis | vanA | 7 | Daptomycin | 0.5-4 |
Teicoplanin | 32->64 | |||
Vancomycin | 256->256 | |||
aph(3′)IIIa | 4 | Daptomycin | 0.5-1 | |
Gentamicin | >500->500 | |||
aac(6′)-aph2" | 11 | Daptomycin | 0.5-2 | |
Gentamicin | >500->500 | |||
aac(6′)-aph2" + aph(3′)IIIa | 17 | Daptomycin | 0.5-8 | |
Gentamicin | >500->500 | |||
Enterococcus faecium | vanA | 27 | Daptomycin | 0.25-8 |
Teicoplanin | 8->64 | |||
Vancomycin | 64->256 | |||
aph(3′)IIIa | 2 | Daptomycin | 4-4 | |
Gentamicin | >500->500 | |||
aac(6′)-aph2" | 5 | Daptomycin | 4-8 | |
Gentamicin | >500->500 | |||
aac(6′)-aph2" + aph(3′)IIIa | 9 | Daptomycin | 0.5-8 | |
Gentamicin | >500->500 | |||
Streptococcus pneumoniae | nc/nc/nc/ncb | 2 | Daptomycin | 0.12-0.12 |
Levofloxacin | 1-1 | |||
nc/nc/nc/Ile460Val | 5 | Daptomycin | 0.12-1 | |
Levofloxacin | 1 | |||
Ser81Phe/Ser79Phe/nc/nc | 12 | Daptomycin | 0.12-0.25 | |
Levofloxacin | 4->8 | |||
Ser81Tyr/Ser79Phe/nc/Ile460Val | 1 | Daptomycin | 0.12 | |
Levofloxacin | 4 | |||
Ser81Phe/Asp83Asn/nc/nc | 1 | Daptomycin | 0.25 | |
Levofloxacin | 8 | |||
Ser81Phe/Asp83Asn/nc/Ile460Val | 1 | Daptomycin | 0.06 | |
Levofloxacin | 8 | |||
tetM | 12 | Daptomycin | 0.12-1 | |
ermB | 9 | Daptomycin | 0.12-0.12 | |
Clindamycin | >1->1 | |||
Erythromycin | >2->2/PICK> | |||
mefE | 7 | Daptomycin | 0.12-0.25 | |
Erythromycin | >2->2 | |||
tetM+ermB | 7 | Daptomycin | 0.12-0.25 | |
Erythromycin | >2->2 | |||
tetM+mefE | 6 | Daptomycin | 0.06-0.25 | |
Erythromycin | >2->2 | |||
Streptococcus mitis | nc/nc/nc/ncc | 3 | Daptomycin | 0.5-1 |
Levofloxacin | 1-1 | |||
Erythromycin | 0.06->2 | |||
nc/nc/Ser494Thr/nc | 5 | Daptomycin | 1-8 | |
Levofloxacin | 1-1 | |||
Erythromycin | 0.06->2 | |||
Ser81Phe/Ser79Ile/Ser494Thr/nc | 1 | Daptomycin | 0.5 | |
Levofloxacin | 4 | |||
Erythromycin | >2 | |||
Ser81Phe/Ser79Phe/nc/nc | 1 | Daptomycin | 2 | |
Levofloxacin | 0.5 | |||
Erythromycin | >2 | |||
Ser81Tyr/Ser79Ile/nc/nc | 1 | Daptomycin | 0.25 | |
Levofloxacin | 8 | |||
Erythromycin | 2 | |||
Ser81Tyr/Ser79Ile/Ser494Thr/nc | 1 | Daptomycin | 1 | |
Levofloxacin | 2 | |||
Erythromycin | 2 | |||
Streptococcus sanguis | nc/nc/nc/nc | 1 | Daptomycin | 2 |
Levofloxacin | 1 | |||
Erythromycin | 0.03 | |||
nc/nc/Ser494/Thrnc | 2 | Daptomycin | 1-1 | |
Levofloxacin | 1-1 | |||
Erythromycin | 0.03->2 | |||
Ser81Phe/Ser79Ile/nc/nc | 1 | Daptomycin | 0.5 | |
Levofloxacin | 1 | |||
Erythromycin | 0.03 | |||
Streptococcus agalactiae | ermA | 1 | Daptomycin | 0.25 |
Clindamycin | ≤0.25 | |||
Erythromycin | >2 | |||
ermA+ermTR | 2 | Daptomycin | 0.25-0.5 | |
Clindamycin | ≤0.25->1 | |||
Erythromycin | 2->2 | |||
ermA+ermC+ermTR | 1 | Daptomycin | 0.25 | |
Clindamycin | >1 | |||
Erythromycin | >2 | |||
ermB | 3 | Daptomycin | 0.06-0.25 | |
Clindamycin | ≤0.25->1 | |||
Erythromycin | 1->2 | |||
Streptococcus bovis | ermB | 11 | Daptomycin | 0.03-0.12 |
Clindamycin | 1->1 | |||
Erythromycin | >2->2 | |||
ermB+ermC | 1 | Daptomycin | 0.06 | |
Clindamycin | >1 | |||
Erythromycin | >2 | |||
ermB+ermTR | 1 | Daptomycin | 0.03 | |
Clindamycin | >1 | |||
Erythromycin | >2 | |||
Streptococcus equisimilis | ermB+ermTR | 1 | Daptomycin | 0.06 |
Clindamycin | >1 | |||
Erythromycin | >2 | |||
ermC+ermTR | 1 | Daptomycin | 0.03 | |
Clindamycin | ≤0.25 | |||
Erythromycin | >2 | |||
Streptococcus intermedius | ermB+ermTR | 1 | Daptomycin | 1 |
Clindamycin | >1 | |||
Erythromycin | >2 | |||
Streptococcus mitis | ermA+mefA | 1 | Daptomycin | 0.5 |
Clindamycin | ≤0.25 | |||
Erythromycin | 2 | |||
ermB | 5 | Daptomycin | 0.5-2 | |
Clindamycin | ≤0.25->1 | |||
Erythromycin | >2->2 | |||
mefA | 5 | Daptomycin | 0.25-1 | |
Clindamycin | ≤0.25-≤0.25 | |||
Erythromycin | >2->2 | |||
Streptococcus oralis | mefA | 4 | Daptomycin | 0.5-2 |
Clindamycin | ≤0.25-≤0.25 | |||
Erythromycin | 2->2 | |||
Streptococcus pyogenes | ermB | 2 | Daptomycin | 0.03-0.06 |
Clindamycin | ≤0.25->1 | |||
Erythromycin | 2->2 | |||
ermTR | 2 | Daptomycin | 0.06-0.06 | |
Clindamycin | ≤0.25-≤0.25 | |||
Erythromycin | >2->2 | |||
mefA | 1 | Daptomycin | 0.03 | |
Clindamycin | ≤0.25 | |||
Erythromycin | >2 | |||
Streptococcus salivarius | ermB | 2 | Daptomycin | 0.12-0.12 |
Clindamycin | 1->1 | |||
Erythromycin | 2->2 | |||
mefA | 1 | Daptomycin | 0.12 | |
Clindamycin | ≤0.25 | |||
Erythromycin | >2 |
Mutations in grlA/gyrA of S. aureus, respectively.
Mutations in gyrA/gyrB/parC/parE of S. pneumoniae, respectively. nc, no change in amino acids
Mutations in gyrA/gyrB/parC/parE of other streptococci, respectively.