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. Author manuscript; available in PMC: 2014 May 20.
Published in final edited form as: Stat Med. 2012 Sep 13;32(11):1865–1876. doi: 10.1002/sim.5601

Figure 6. Net benefit against plotted against threshold probability for a molecular marker of prostate cancer, with an invasive diagnostic test conditional upon the marker findings.

Figure 6

Thick grey line: biopsy all men. Thick black line: biopsy no men. Thin black line: biopsy if HK test positive. Thin grey line: biopsy if HK test positive and a TRUS given after a positive HK test is also positive, assuming a physician would do not more than 10 TRUS to find one cancer (left panel); a physician would do no more than 20 TRUS to find one cancer (center panel); a physician would do no more than 50 TRUS to find one cancer (right panel).The conditional strategy is now found to be preferable for certain threshold probabilities.