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. 2012 Nov 14;4(12):1244–1260. doi: 10.1002/emmm.201201650

Figure 6. Type I IFN and not p65 are important for lymphocyte recruitment.

Figure 6

Mice were inoculated with intranasal RV1B or PBS and harvested at various time points.

  1. P65+/− mice had similar BAL lymphocytes at 8–96 h compared to p65+/+ mice (n = 2–3 independent experiments with 4–6 mice per group or per time point per experiment), and had similar levels of BAL CCL5, CXCL10, and CXCL11 (n = 2 independent experiments with 4–6 mice per group or per time point per experiment). Data was analysed by two-way ANOVA, ns = not significant.
  2. IFNAR1−/− mice had reduced BAL lymphocytes from 48–72 h post infection compared to controls (wt, n = 2–3 independent experiments with 4–6 mice per group or per time point per experiment), and reduced BAL CCL5 at 24–48 h, reduced CXCL10 at 8 h elevated CXCL11 at 8 h which was reduced at 72 h (n = 2 independent experiments with 4–6 mice per group or per time point per experiment). Data was analysed by two-way ANOVA, ***p < 0.001, **p < 0.01 as indicated, all data are expressed as mean ± SEM.