Table 1.
Peptides synthesised in this investigation.[a]
| Peptide target | Yield [%][b] | |
|---|---|---|
| control | DWSFYLLYYTEFT | 23 |
| p13T | DWSFYLLYYTEFpT | 10 |
| p10T | DWSFYLLYYpTEFT | 8 |
| p9Y | DWSFYLLYpYTEFT | 18 |
| p8Y | DWSFYLLpYYTEFT | 8 |
| p5Y | DWSFpYLLYYTEFT | 8 |
| p3S | DWpSFYLLYYTEFT | 12 |
| p3Sp10T | DWpSFYLLYYpTEFT | 9 |
[a]
Phosphopeptide variants are labelled pX, where X denotes the phosphorylated amino acid side chain. All peptides were N-terminally acetylated and C-terminally amidated.
[b]
Quoted yields are of pure peptide obtained after purification by preparative HPLC.