Table 3.

Performance characteristics for the diagnosis of AKI using estimation methods relative to known baseline: overall and in patients with eGFR < or ≥ 60 ml/min per 1.73 m²

Estimation Methoda	Sensitivity	Specificity	Positive Predictive Value	Negative Predictive Value
Overall
Single eGFR 75	0.70	0.91	0.57	0.95
Basic multiple imputation	0.57	0.96	0.70	0.93
Basic multiple imputation + SCr	0.55	0.97	0.76	0.93
Full multiple imputation	0.71	0.92	0.60	0.95
Full multiple imputation + SCr	0.57	0.97	0.76	0.93
Patients with eGFR < 60 ml/min per 1.73 m2
Single eGFR 75	1	0.49	0.34	1
Basic multiple imputation*	0.92	0.78	0.53	0.97
Basic multiple imputation + SCr	0.83	0.87	0.63	0.95
Full multiple imputation	0.95	0.66	0.42	0.98
Full multiple imputation + SCr	0.86	0.84	0.59	0.96
Patients with eGFR ≥ 60 ml/min per 1.73 m2
Single eGFR 75	0.61	0.99	0.87	0.94
Basic multiple imputation	0.46	0.99	0.88	0.92
Basic multiple imputation + SCr	0.45	0.99	0.87	0.92
Full multiple imputation	0.63	0.97	0.75	0.95
Full multiple imputation + SCr	0.47	0.99	0.91	0.92

Estimated GFR based on minimum serum creatinine during the first 7 days of hospitalization. eGFR, estimated GFR; eGFR 75, estimated GFR = 75 ml/min per 1.73 m²; SCr, serum creatinine;.

^aBasic multiple imputation = three-variable multiple imputation; basic multiple imputation with SCr = basic three-variable multiple imputation plus minimum inpatient serum creatinine; full multiple imputation = full-variable multiple imputation; full multiple imputation with SCr = full variable multiple imputation plus minimum inpatient serum creatinine.